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  • Title: Rosai-Dorfman disease presenting as bilateral eyelid swellings.
    Author: Jogai S, Temmim L, Al-Baghli A, Adesina AO.
    Journal: Med Princ Pract; 2006; 15(2):163-5. PubMed ID: 16484848.
    Abstract:
    OBJECTIVE: To report a case of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) in an extranodal site with unusual presentation. CASE PRESENTATION: A 19-year-old girl presented with bilateral upper eyelid swellings of 2 years duration due to tumor. The masses were excised and sent for histopathological examination. Microscopic examination revealed similar features in both masses in the form of a collection of large histiocytic cells showing emperipolesis (lymphocytophagocytosis). The histiocytic cells stained positively with S-100 protein and CD68. The background comprised small lymphocytes and plasma cells. Based on the overall features a diagnosis of sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease was made. CONCLUSION: The present case highlights one of the forms in which extranodal Rosai-Dorfman disease can manifest itself. It is important to keep this differential diagnosis in mind whenever such histopathological features are encountered.
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