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  • Title: Protein-mediated DNA loops: effects of protein bridge size and kinks.
    Author: Douarche N, Cocco S.
    Journal: Phys Rev E Stat Nonlin Soft Matter Phys; 2005 Dec; 72(6 Pt 1):061902. PubMed ID: 16485969.
    Abstract:
    This paper focuses on the probability that a portion of DNA closes on itself through thermal fluctuations. We investigate the dependence of this probability upon the size of a protein bridge and/or the presence of a kink at half DNA length. The DNA is modeled by the wormlike chain model, and the probability of loop formation is calculated in two ways: exact numerical evaluation of the constrained path integral and the extension of the Shimada and Yamakawa saddle point approximation. For example, we find that the looping free energy of a 100-base-pairs DNA decreases from 24 kBT to 13 kBT when the loop is closed by a protein of r=10 length. It further decreases 5 kBT to when the loop has a kink of 120 degrees at half-length.
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