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  • Title: Development of antibodies against the putative proteinase maturation protein A in relation to pneumococcal carriage and otitis media.
    Author: Bogaert D, Holmlund E, Lahdenkari M, de Groot R, Kilpi T, Hermans PW, Kayhty H.
    Journal: FEMS Immunol Med Microbiol; 2006 Mar; 46(2):166-8. PubMed ID: 16487297.
    Abstract:
    The putative pneumococcal proteinase maturation protein A is a potential pneumococcal vaccine candidate. We examined serum antipneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal proteinase maturation protein A antibodies is associated with pneumococcal contacts. A higher antipneumococcal proteinase maturation protein A antibody concentration at 18 months of age tends to predict for a lower risk of pneumococcal acute otitis media in the following 6 months (relative risk: 0.84, 95% confidence interval: 0.62-1.13).
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