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  • Title: [Analytical interference in determination of procalcitonin by PCT-Q (Brahms)].
    Author: Désidéri-Vaillant C, Rouby Y, Cardon N, Vinsonneau U, Laborde JP.
    Journal: Pathol Biol (Paris); 2006 May; 54(5):293-5. PubMed ID: 16488089.
    Abstract:
    Procalcitonin (PCT) is a biological marker of infection. We present the cas of a patient who has presented a high concentration of PCT with PCT-Q test (Brahms). At the same time, the concentration of CRP is remained low, which is no physiological. Then, PCT concentration has been determinated with an automatic system (Kryptor-Brahms) and finded at low than 0.5 microg/l. Brahms company has searched an analytical interference: human anti-mouse antibodies (HAMA) were positive. If PCT concentration stay a marker of infection for the most part, this case show that biologists have to keep in mind that immunological assays remain submitted to interferences.
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