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  • Title: Genomic structure and transcriptional regulation of the penaeidin gene family from Litopenaeus vannamei.
    Author: O'Leary NA, Gross PS.
    Journal: Gene; 2006 Apr 12; 371(1):75-83. PubMed ID: 16488092.
    Abstract:
    Penaeidins are a family of shrimp antimicrobial peptides that have a unique molecular structure consisting of a highly conserved leader peptide followed by an N-terminal proline-rich domain and a C-terminal cysteine-rich domain. Three distinct classes of penaeidins, named PEN2, PEN3, and PEN4, are expressed in the hemocytes of the Pacific white shrimp, Litopenaeus vannamei. Multiple isoforms, generated by substitutions and deletions within the proline and cysteine-rich domains, have been reported at the mRNA level for all three classes of penaeidins suggesting that this is a highly diverse gene family; however, the genetic mechanisms by which sequence variability in the penaeidin gene family is generated are unknown. The present study examines the genomic sources for both class and isoform diversity in the penaeidin family. We show that each penaeidin class is encoded by a unique gene and that isoform diversity is generated by polymorphism within each penaeidin gene locus. Furthermore, the genomic regions upstream of each penaeidin gene were partially characterized and found to drive transcription.
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