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  • Title: Caspase-3 induced apoptosis in transgenic zebrafish.
    Author: Chakraborty C, Saha G, Sarkar B, Pal S, Chatterjee TK, Sadhu AK.
    Journal: Biotechnol Lett; 2006 Feb; 28(3):189-96. PubMed ID: 16489497.
    Abstract:
    Zebrafish is an attractive model organism for studying apoptosis development because of its genetic accessibility. Here we describe the induction of clonally derived apoptosis in transgenic zebrafish expressing mouse caspase-3 (CASP3) under control of the zebrafish beta-actin promoter (betap). Visualization of apoptotic cells, expressing a chimeric transgene encoding CASP3 fused to green fluorescent protein (GFP) gene, revealed that apoptosis arose in the thymus, spread locally into gill arches and retro-orbital soft tissue, and then disseminated into abdominal organs like testis, kidney. This transgenic model provides a platform for over-expression of caspase-3 induced extensive apoptosis in embryos and adult.
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