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  • Title: Inhibition of Streptococcus mutans adherence to hydroxyapatite with combinations of alkyl phosphates and nonionic surfactants.
    Author: Olsson J, Carlén A, Holmberg K.
    Journal: Caries Res; 1991; 25(1):51-7. PubMed ID: 1649004.
    Abstract:
    Seven alkyl phosphate derivatives and three nonionic surfactants were examined for their ability to inhibit the adherence of 3H-labelled cells of Streptococcus mutans to hydroxyapatite (HA) treated with buffer (BHA) or parotid saliva (SHA). None of the compounds alone hindered binding of bacteria to BHA or SHA effectively. A combination of certain of the alkyl phosphates, notably a disodium phosphate of 1-octadecanol, and nonionic surfactant at a 1:1 molar ratio gave a strong inhibition of S. mutans adherence. Treatment of SHA with this combination resulted in 98% reduction of adherence. Adsorption of the two types of surface-active agents alone and in combinations was studied using 14C-labelled agents. Electrophoretic measurements revealed that surfaces treated with only alkyl phosphate became highly negatively charged, while surfaces treated with the combination had a zeta-potential of around zero. The results suggest that treatment with surfactants might be used to interfere with bacterial adherence on the tooth surface.
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