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  • Title: Serum antibodies against circulating influenza strains among vaccinated and unvaccinated general practitioners during two consecutive years (2002-2003).
    Author: Michiels B, Philips H, Coenen S, Denekens J, Van Royen P.
    Journal: Vaccine; 2006 Apr 12; 24(16):3145-52. PubMed ID: 16490288.
    Abstract:
    Efficacy studies have not answered the question whether influenza vaccination among general practitioners (GPs) has a substantial additive effect on their immunity. To evaluate this effect the influenza antibody titres in vaccinated and unvaccinated GPs were compared in a controlled trial during two consecutive winter periods (2002-2003 and 2003-2004). The seroprotection rates against the circulating A/H3N2 influenza virus amount to 80% and 42% in the unvaccinated group in 2002 and 2003, respectively. In the vaccinated GPs the seroprotection rate increases from 91% to 96% in 2002 and from 70% to 83% in 2003 after vaccination. Besides vaccination, the (high) basic antibody titre before vaccination and working in a child and family preventive medicine unit were predicting a protective antibody level in GPs.
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