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  • Title: Bacterial vaginosis in early pregnancy is associated with low birth weight and small for gestational age, but not with spontaneous preterm birth: a population-based study on Danish women.
    Author: Thorsen P, Vogel I, Olsen J, Jeune B, Westergaard JG, Jacobsson B, Møller BR.
    Journal: J Matern Fetal Neonatal Med; 2006 Jan; 19(1):1-7. PubMed ID: 16492583.
    Abstract:
    OBJECTIVE: To analyze the association between bacterial vaginosis (BV) in early pregnancy and preterm birth, low birth weight (LBW) and small for gestational age (SGA) in a Danish population. METHODS: A geographically defined population-based prospective study of Danish-speaking pregnant women over18 years of age enrolled before week 24 and followed until delivery. BV was diagnosed by Amsel's clinical criteria at enrolment. RESULTS: At enrolment, 13.7% had BV. BV was not associated with an increased risk of spontaneous preterm birth (crude OR 0.8 (0.5-1.5)). Nulliparity was found to affect birth weight to such a degree that this variable was used for stratification. In nulliparous women BV was associated with LBW (adj. OR 4.3 (1.5-12)) and SGA (adj. OR 1.6 (0.7-3.1)) compared to nulliparous without BV. No such associations were seen for multiparous women with BV. CONCLUSIONS: BV was not associated with spontaneous preterm birth, but was associated with both LBW and SGA in nulliparous women.
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