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  • Title: A randomized controlled trial of adjunctive erythromycin in women with idiopathic preterm labor.
    Author: Rajaei M, Sultani M, Zare S.
    Journal: J Matern Fetal Neonatal Med; 2006 Jan; 19(1):17-20. PubMed ID: 16492585.
    Abstract:
    OBJECTIVE: Our purpose was to determine the effects of erythromycin among hospitalized women with idiopathic preterm labor who were treated with tocolytics. METHODS: This prospective randomized trial was conducted in patients with preterm labor of no clinically identifiable cause between 26 and 34 weeks of gestation, who were receiving magnesium sulfate. A total of 136 patients were screened. Of these, 80 eligible, consenting patients were randomized to receive either 400 mg erythromycin or placebo orally every 6 hours for 10 days. Necessary statistical comparisons were preformed using unpaired two-tailed Student's t-test and Chi-square analysis. RESULTS: In comparing the 38 erythromycin and 42 placebo patients there was improvement in the treatment-to-delivery interval (33.33 +/- 18.36 versus 26.88 +/- 13.9 days, respectively), mean gestational age at delivery (36.11 +/- 2.33 versus 34.36 +/- 2.33 weeks, respectively), mean birth weight (2722.31 +/- 511.65 versus 2419.41 +/- 513.54 g, respectively), and reduced neonatal admission to NICU (36.8% versus 60.19%) in the erythromycin group. CONCLUSION: In patients with idiopathic preterm labor the adjunctive use of erythromycin therapy appeared safe and well tolerated and resulted in a statistically significant delay from admission to delivery and improved gestational age at delivery, mean birth weight and neonatal outcome.
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