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  • Title: Design and synthesis of pyrankacin: a pyranmycin class of broad-spectrum aminoglycoside antibiotic.
    Author: Rai R, Chen HN, Czyryca PG, Li J, Chang CW.
    Journal: Org Lett; 2006 Mar 02; 8(5):887-9. PubMed ID: 16494466.
    Abstract:
    A novel broad-spectrum aminoglycoside antibiotic, pyrankacin, has been prepared. In addition to the synthetic innovation in dideoxygenation and regioselective Staudinger reduction, we have obtained prominent antibacterial activity against several clinically important pathogens in the course of this work.
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