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  • Title: Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole.
    Author: Quan H, Cao YY, Xu Z, Zhao JX, Gao PH, Qin XF, Jiang YY.
    Journal: Antimicrob Agents Chemother; 2006 Mar; 50(3):1096-9. PubMed ID: 16495278.
    Abstract:
    In vitro interaction of fluconazole and berberine chloride was investigated against 40 fluconazole-resistant clinical isolates of Candida albicans. Synergism in fungistatic activity was found with the checkerboard microdilution assay. The findings of agar diffusion tests and time-kill curves confirmed the synergistic interaction, but no antagonistic action was observed.
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