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  • Title: Modulation of human neutrophil functions in vitro by Treponema denticola major outer sheath protein.
    Author: Puthengady Thomas B, Sun CX, Bajenova E, Ellen RP, Glogauer M.
    Journal: Infect Immun; 2006 Mar; 74(3):1954-7. PubMed ID: 16495573.
    Abstract:
    In this study of human polymorphonuclear leukocytes (PMNs), pretreatment with Treponema denticola major outer sheath protein (Msp) inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)-induced chemotaxis, phagocytosis of immunoglobulin G-coated microspheres, fMLP-stimulated calcium transients, and actin assembly. Msp neither altered oxidative responses to phorbol myristate or fMLP nor induced apoptosis. Msp selectively impairs chemotaxis and phagocytosis by impacting the PMN cytoskeleton.
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