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  • Title: Increased virulence of modified-live infectious laryngotracheitis vaccine virus following bird-to-bird passage.
    Author: Guy JS, Barnes HJ, Smith L.
    Journal: Avian Dis; 1991; 35(2):348-55. PubMed ID: 1649591.
    Abstract:
    Modified-live (ML) infectious laryngotracheitis (ILT) vaccine viruses, both tissue-culture-origin (TCO) and chicken-embryo-origin (CEO), were passaged 20 times in specific-pathogen-free chickens. After serial bird-to-bird passage, increased virulence was observed for CEO virus but not TCO virus. Increased mortality and increased severity and duration of respiratory disease were observed in chickens inoculated with chicken-passaged CEO viruses; only mild respiratory disease (no mortality) occurred in chickens inoculated with chicken-passaged TCO viruses. These findings suggest that ML ILT vaccine viruses may increase in virulence after bird-to-bird passage.
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