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  • Title: Childhood sexual abuse in relation to neurobiological challenge tests in patients with borderline personality disorder and normal controls.
    Author: Zweig-Frank H, Paris J, Ng Ying Kin NM, Schwartz G, Steiger H, Vasavan Nair NP.
    Journal: Psychiatry Res; 2006 Mar 30; 141(3):337-41. PubMed ID: 16497388.
    Abstract:
    This study examined whether abnormal responses to neurobiological challenge tests in borderline personality disorder (BPD) are related to a history of childhood sexual abuse (CSA). We compared patients meeting BPD criteria (n=24), with and without histories of CSA, with normal controls (n=12) on the results of challenges with meta-chlorphenylpiperazine (m-CPP), pyridostigmine and clonidine. No differences were found between abused and non-abused patients with BPD. These results do not support the hypothesis that CSA is directly related to neurobiological abnormalities in BPD.
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