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  • Title: Clinical predictors of self-limited urinalysis abnormality in childhood Henoch-Schönlein purpura nephritis.
    Author: Hung SH, Yang YH, Lee CC, Wang LC, Lin YT, Chiang BL.
    Journal: Acta Paediatr; 2006 Mar; 95(3):306-11. PubMed ID: 16497641.
    Abstract:
    BACKGROUND AND AIM: The majority of patients (85-95%) with Henoch-Schönlein purpura nephritis (HSPN) suffer from a prolonged course of urinalysis abnormality. We sought to identify favourable prognostic factors predicting a self-limited urinalysis abnormality within 1 y. METHODS: Fifty-eight HSPN patients admitted to the University Hospital between 1990 and 2003 were retrospectively analysed. Detailed information on clinical and laboratory manifestations on admission and sequential follow-up clinics were recorded. The chi2 or Fisher's exact test were used for univariate analysis, and multiple logistic regression was used for multivariate analysis. RESULTS: The study cohort included 31 boys and 27 girls, with a mean age of onset of 8.0+/-4.3 y and a median follow-up duration of 5.9 y (range 1 to 25). Of 58 patients, 39 (67.3%) had a self-limited urinalysis abnormality within 1 y. On multivariate analysis, onset age less than 9 (p=0.038), low-grade proteinuria (p=0.044) and interval between purpura onset and renal manifestations less than 2 wk (p=0.005) predicted self-resolved urinalysis abnormality within 1 y. With two or more predictive factors, the sensitivity for short-term course was 84.6%, the specificity was 73.7%, and the positive predictive value was 84.8%. CONCLUSION: A small number of variables were important for detecting a favourable short-term course of urinalysis abnormality.
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