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  • Title: Dendritic cell apoptosis in the maintenance of immune tolerance.
    Author: Chen M, Wang YH, Wang Y, Huang L, Sandoval H, Liu YJ, Wang J.
    Journal: Science; 2006 Feb 24; 311(5764):1160-4. PubMed ID: 16497935.
    Abstract:
    Apoptosis in the immune system is critical for maintaining self-tolerance and preventing autoimmunity. Nevertheless, inhibiting apoptosis in lymphocytes is not alone sufficient to break self-tolerance, suggesting the involvement of other cell types. We investigated whether apoptosis in dendritic cells (DCs) helps regulate self-tolerance by generating transgenic mice expressing the baculoviral caspase inhibitor, p35, in DCs (DC-p35). DC-p35 mice displayed defective DC apoptosis, resulting in their accumulation and, in turn, chronic lymphocyte activation and systemic autoimmune manifestations. The observation that a defect in DC apoptosis can independently lead to autoimmunity is consistent with a central role for these cells in maintaining immune self-tolerance.
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