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  • Title: A pyrimidine-beta-carboline and other alkaloids from Annona foetida with antileishmanial activity.
    Author: Costa EV, Pinheiro ML, Xavier CM, Silva JR, Amaral AC, Souza AD, Barison A, Campos FR, Ferreira AG, Machado GM, Leon LL.
    Journal: J Nat Prod; 2006 Feb; 69(2):292-4. PubMed ID: 16499336.
    Abstract:
    Bioassay-guided fractionation of the bark extract of Annona foetida afforded a new antileishmanial pyrimidine-beta-carboline alkaloid, N-hydroxyannomontine (1), together with the previously reported annomontine (2), O-methylmoschatoline (3), and liriodenine (4). The structure of compound 1 was established on the basis of extensive 1D and 2D NMR and MS analyses. This is the third reported pyrimidine-beta-carboline-type alkaloid and is particularly important for Annona genus chemotaxonomy. In addition, all compounds exhibit in vitro antileishmanial activity against promastigote forms of Leishmania braziliensis. Compounds 2 and 4 showed better activity than compounds 1 and 3 against L. braziliensis. Compound 2 was not active against L. guyanensis.
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