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  • Title: Electrochemical study of lincomycin on a multi-wall carbon nanotubes modified glassy carbon electrode and its determination in tablets.
    Author: Wu Y, Ye S, Hu S.
    Journal: J Pharm Biomed Anal; 2006 Jun 07; 41(3):820-4. PubMed ID: 16503106.
    Abstract:
    Multi-wall carbon nanotubes (MWNTs) were dispersed in dihexadecylphosphate (DHP), sodium dodecylbenzenesulfonate (SDBS), and Nafion to give a homogeneous and stable suspension, respectively. MWNTs film in different solvents was fabricated onto a glassy carbon electrode (GCE) with an easy and convenient method. It was found that on MWNTs-DHP film lincomycin exhibited a well-defined oxidation peak. The electrochemical behavior of lincomycin at coated GCE was investigated by cyclic voltammetry and chronocoulometry. The MWNTs-DHP film modified glassy carbon electrode shows obvious electrocatalytic activity to the oxidation of lincomycin, since it greatly enhances the oxidation peak current of lincomycin as well as lowers its oxidation overpotential. Based on this, a very sensitive and simple voltammetric method was developed for the measurement of lincomycin. A sensitive linear voltammetric response for lincomycin was obtained in the concentration range of 4.5x10(-7) to 1.5x10(-4) mol/l, and the detection limit is 2.0x10(-7) mol/l using linear sweep voltammetry. Compared with other methods, this proposed method possesses many advantages such as very low detection limit, fast response, low cost and simplicity. The practical application was demonstrated to determine lincomycin in tablets with good result.
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