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  • Title: Arylanthranilodinitriles: a new biaryl class of antileishmanial agents.
    Author: Singh FV, Vatsyayan R, Roy U, Goel A.
    Journal: Bioorg Med Chem Lett; 2006 May 15; 16(10):2734-7. PubMed ID: 16503140.
    Abstract:
    A series of anthranilodinitrile-based biaryls were synthesized and evaluated in vitro against extracellular promastigotes and intracellular amastigotes of Leishmania donovani. Among various screened compounds, a biaryl with trifluoromethyl group 5f showed 83% inhibition against promastigotes and 70% inhibition against amastigotes of L. donovani at 8 and 20microg/mL concentrations, respectively.
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