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  • Title: Intensive chemotherapy with autologous peripheral blood stem cell transplantation during a 10-year period in 64 patients with germ cell tumor.
    Author: Müller AM, Ihorst G, Waller CF, Dölken G, Finke J, Engelhardt M.
    Journal: Biol Blood Marrow Transplant; 2006 Mar; 12(3):355-65. PubMed ID: 16503505.
    Abstract:
    Despite gratifying cure rates in germ cell tumors, conventional-dose chemotherapy achieves long-term remissions in less than 50% of patients at high risk. High-dose chemotherapy followed by autologous (auto) peripheral blood stem cell transplantation (PBSCT) has shown impressive remission rates in high-risk and relapsed germ cell tumors. We report on 64 consecutive patients with high- (n=39), intermediate- (n=18), and refractory or relapsed low- (n=7) risk germ cell tumors who underwent auto-PBSCT between January 1993 and February 2003. PBSCTs were performed as a single (n=40) or repeated (n=24) transplantation using either etoposide, ifosfamide, and carboplatin (n=80) or related protocols (paclitaxel, ifosfamide, carboplatin, etoposide [n=7]; carboplatin, etoposide, thiotepa [n=4]). With a median follow-up of 6 years, estimated 2- and 5-year overall survivals were 77.2% (95% confidence interval [CI] 66.7-87.7) and 73.1% (95% CI 61.7-84.5), respectively. We observed unfavorable results in those patients showing refractoriness to cisplatin (hazard ratio 20.36; 95% CI 6.64-62.47) or no response to induction chemotherapy (hazard ratio 10.67; 95% CI 1.37-83.37). Auto-PBSCT was well tolerated, showed objective antitumor activity, and achieved long-term survival in patients at high risk and with relapse. Our data suggest that auto-PBSCT can increase response rates and may improve the outcome in these patients.
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