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  • Title: Specific cleavage of chicken alpha A-globin and human c-Ha-ras genes by two molecular forms of calf thymus topoisomerase I.
    Author: Bronstein IB, Gromova II, Razin SV.
    Journal: Mol Cell Biochem; 1991 Mar 13; 101(2):115-24. PubMed ID: 1650425.
    Abstract:
    Two molecular forms of topoisomerase I differing in size and sensitivity to camptothecin were isolated from calf thymus. Mapping of topo I cleavage sites of the cloned chicken alpha A-globin and human c-Ha-ras genes was carried out. Camptothecin was shown to affect site specificity of the topoisomerases.
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