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  • Title: Studies on the novel alpha-glucosidase inhibitory activity and structure-activity relationships for andrographolide analogues.
    Author: Dai GF, Xu HW, Wang JF, Liu FW, Liu HM.
    Journal: Bioorg Med Chem Lett; 2006 May 15; 16(10):2710-3. PubMed ID: 16504503.
    Abstract:
    A series of analogues of andrographolide were synthesized and evaluated as novel alpha-glucosidase inhibitors. Among them compound 23, 15-p-methoxylbenzylidene 14-deoxy-11,12-didehydroandrographolide, was a potent inhibitor against alpha-glucosidase whose IC(50) value was 16microM. The structure-activity relationships were also discussed.
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