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  • Title: Early results of orthotopic liver transplantations using the technique of inferior vena cava anastomosis.
    Author: Remiszewski P, Zieniewicz K, Krawczyk M.
    Journal: Transplant Proc; 2006; 38(1):237-9. PubMed ID: 16504712.
    Abstract:
    INTRODUCTION: We compared early results of orthotopic liver transplantation (OLT) in adults using the classic versus piggyback technique of inferior vena cava anastomosis. PATIENTS AND METHODS: We analyzed 100 consecutive patients who underwent OLT from 2000 to 2003. Group A included 50 patients operated with the classic technique with venovenous extracorporeal bypass, and group B, 50 patients with the piggyback technique. The age range of the patients in group A was 21 to 63 years (mean, 43.5 years) and in group B, 20 to 65 years (mean, 46 years). The gender F/M distribution in group A was 24/26 and in group B, 28/22. The indications for OLT were acute hepatic failure (8%), chronic liver insufficiency (77%), liver tumors (8%), metabolic diseases (5%), and Budd-Chiari syndrome (2%). The degrees of liver insufficiency evaluated according to the Child classification were A, 18; B, 52; and C, 30 patients. The urgency for OLT on the United Network for Organ Sharing (UNOS) scale was UNOS 1-group A, 2 patients; group B, 7 patients; UNOS 2a-group A, 7 patients; group B, 6 patients; UNOS 2b-group A, 29 patients; group B, 30 patients; UNOS 3-group A, 12 patients; group B, 7 patients. RESULTS: The average cold ischemia time in group A was 530 minutes and in group B, 515 minutes. The average results on the 10th postoperative day: aspartate transaminase (AST)-group A, 52.5 U/L; group B, 54.5 U/L; alanine transaminase (ALT)-group A, 131.5 U/L; group B, 153 U/L; gamma glutyl transpeptidase (GGTP)-group A, 299 U/L; group B, 285.5 U/L; alkaline phosphatase (ALP)-group A, 164 U/L; group B, 150.5 U/L; bilirubin-group A, 4.37 mg%; group B, 2.71 mg%; activated partial thromboplastin time (APTT)-group A, 37.6 seconds; group B, 34.8 seconds; platelets (PLT)-group A, 167 10(2)/mm(2); group B, 171 10(2)/mm(2). The incidence of postoperative complications was 36% in group A; it was 30% in group B. The mean hospitalization times in the surgical department were 17 days in group A and 16 days in group B. CONCLUSIONS: The early results, morbidity and mortality with both applied techniques were similar. Individualization in qualifying the patients for a given operative technique is important. The lower complication rate and reduced treatment cost of the piggyback technique group suggested advantages of this technique when compared with the classical OLT technique.
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