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  • Title: N-fatty acyl compounds inhibit myristoyl acylation of pp60v-src and reduce tumorigenicity of Rous sarcoma virus-infected cells.
    Author: Shoji S, Tsujita R, Hamuro T, Funakoshi T, Kubota Y.
    Journal: Biochem Int; 1991 Jan; 23(1):15-23. PubMed ID: 1650555.
    Abstract:
    Prevention of NH2-terminal myristoylation of pp60v-src was determined with N-fatty acyl glycinal derivatives. Of all the compounds tested, N-myristoyl and N-lauroyl glycinal diethylacetal, N-myristoyl glycyl glycinal diethylacetal, and N-myristoyl-4-aminobutyl aldehyde diethylacetal strongly inhibited myristoylation of pp60v-src; but N-myristoyl diglycyl, N-myristoyl triglycyl, N-decanoyl glycinal diethylacetal, and N-palmitoyl glycinal diethylacetal did not. N-Myristoyl glycinal diethylacetal (25 or 50 microM) suppressed both morphological transformation and colony formation of Rous sarcoma virus-infected chick embryo fibroblasts.
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