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  • Title: [Drug hypersensitivity syndrome associated with a primary HHV6 infection].
    Author: Debarbieux S, Deroo-Berger MC, Grande S, Najioullah F, Kanitakis J, Faure M, Claudy A.
    Journal: Ann Dermatol Venereol; 2006 Feb; 133(2):145-7. PubMed ID: 16508598.
    Abstract:
    INTRODUCTION: Drug hypersensitivity syndrome is a severe life-threatening drug reaction. An association between this syndrome and HHV6 reactivation has been hypothesized. CASE-REPORT: A 45 year-old women was treated with sulfasalazine for polyarthralgia. One month after beginning the treatment, she developed a drug hypersensitivity syndrome with severe acute hepatic failure. HHV6 serology and serum PCR revealed a primary HHV6 infection. DISCUSSION: We report the second case of drug hypersensitivity syndrome associated with a primary HHV6 infection. An immunological disorder may explain such an association by increasing viral replication. Detection and titration of anti-HHV6 antibodies in each case of drug hypersensitivity syndrome should help to confirm this association and possibly modify treatment strategy.
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