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  • Title: Antioxidant activity of beta-blockers: an effect mediated by scavenging reactive oxygen and nitrogen species?
    Author: Gomes A, Costa D, Lima JL, Fernandes E.
    Journal: Bioorg Med Chem; 2006 Jul 01; 14(13):4568-77. PubMed ID: 16510286.
    Abstract:
    The therapeutic effects of beta-blockers are normally explained by their capacity to block the beta-adrenoceptors, however, some of the beneficial cardiovascular effects shown by this group of compounds have already been associated with the antioxidant properties that some of them seem to possess. The beta-blockers atenolol, labetalol, metoprolol, pindolol, propranolol, sotalol, timolol, and carvedilol were tested for their putative scavenging activity for ROS (O(2)(-), H(2)O(2), HO(.), HOCl, and ROO(.)) and RNS ((.)NO and ONOO(-)). Some of the studied compounds are effective ROS and/or RNS scavengers, these effects being possibly useful in preventing oxidative damage verified in hypertension as well as in other cardiovascular diseases that frequently emerge in association with oxidative stress.
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