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  • Title: Synthesis of multisubstituted quinolines from Baylis-Hillman adducts obtained from substituted 2-chloronicotinaldehydes and their antimicrobial activity.
    Author: Narender P, Srinivas U, Ravinder M, Rao BA, Ramesh Ch, Harakishore K, Gangadasu B, Murthy US, Rao VJ.
    Journal: Bioorg Med Chem; 2006 Jul 01; 14(13):4600-9. PubMed ID: 16510289.
    Abstract:
    Baylis-Hillman acetates were synthesized from substituted 2-chloronicotinaldehydes and were conveniently transformed into multisubstituted quinolines and cyclopenta[g]quinolines on reaction with nitroethane or ethyl cyanoacetate via a successive S(N)2'-S(N)Ar elimination strategy. Thus, synthesized quinolines were evaluated for antimicrobial activity and found having substantial antibacterial and antifungal activity.
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