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  • Title: Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis.
    Author: Bertinotti L, Mortilla M, Conforti ML, Colangelo N, Nacci F, Del Rosso A, Fonda C, Casale R, Matucci-Cerinic M, Pignone A.
    Journal: J Rheumatol; 2006 Mar; 33(3):546-51. PubMed ID: 16511924.
    Abstract:
    OBJECTIVE: . Involvement of the central nervous system (CNS) in systemic sclerosis (SSc) is rare. Proton magnetic resonance spectroscopy (1H-MRS) assesses in vivo cerebral metabolites. We investigated the biochemical modifications of the CNS in SSc. METHODS: N-acetylaspartate/creatine ratio (NAA/Cr) and choline/creatine ratio (Cho/Cr) at right centrum semiovale (RCS) and at right basal ganglia (RBG) were evaluated by 1H-MRS in 12 patients with limited (lSSc) and 8 patients with diffuse SSc (dSSc) and 20 control subjects. RESULTS: With 1H-MRS, a significant reduction of NAA/Cr ratio at RBG (p < 0.02) and at RCS (p < 0.002) was detected in SSc patients. Cho/Cr ratio was increased (p < 0.02) in the RCS, but not in RBG. In patients with lSSc, a significant reduction of NAA/Cr was detected in RCS but not in RBG. CONCLUSION: Evidence of neuroaxonal damage strongly suggests the existence of CNS involvement in SSc.
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