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  • Title: Proteomic analysis of mature melanosomes from the retinal pigmented epithelium.
    Author: Azarian SM, McLeod I, Lillo C, Gibbs D, Yates JR, Williams DS.
    Journal: J Proteome Res; 2006 Mar; 5(3):521-9. PubMed ID: 16512666.
    Abstract:
    The protein content of melanosomes in the retinal pigment epithelium (RPE) was analyzed by mass spectrometry. More than 100 proteins were found to be common to two out of three variations of sample preparation. Some proteins normally associated with other organelles were detected. Several lysosomal enzymes were detected, with the presence of cathepsin D confirmed by immunoelectron microscopy, thus supporting the previously suggested notion that melanosomes may contribute to the degradation of ingested photoreceptor outer segment disks.
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