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  • Title: Induction of apoptosis by paclitaxel in human oral carcinoma cells.
    Author: Nonaka M, Ikeda H, Fujisawa A, Uehara M, Inokuchi T.
    Journal: Int J Oral Maxillofac Surg; 2006 Jul; 35(7):649-52. PubMed ID: 16513327.
    Abstract:
    The present study investigated induction of apoptosis in NB-1 oral carcinoma cells by paclitaxel and the expression of Bcl-2 and Bax in relation to this apoptotic cell death. Paclitaxel induced apoptotic cell death in NB-1 cells in a dose- and a time-dependent manner. The present results suggest that paclitaxel can induce apoptosis of NB-1 cells, which may be mediated by down-regulation of Bcl-2 together with up-regulation of Bax.
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