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  • Title: Subunit a of cytochrome o oxidase requires both YidC and SecYEG for membrane insertion.
    Author: du Plessis DJ, Nouwen N, Driessen AJ.
    Journal: J Biol Chem; 2006 May 05; 281(18):12248-52. PubMed ID: 16513637.
    Abstract:
    The Escherichia coli YidC protein belongs to the Oxa1 family of membrane proteins that facilitate the insertion of membrane proteins. Depletion of YidC in E. coli leads to a specific defect in the functional assembly of major energy transducing complexes such as the F1F0 ATPase and cytochrome bo3 oxidase. Here we report on the in vitro reconstitution of the membrane insertion of the CyoA subunit of cytochrome bo3 oxidase. Efficient insertion of in vitro synthesized pre-CyoA into proteoliposomes requires YidC, SecYEG, and SecA and occurs independently of the proton motive force. These data demonstrate that pre-CyoA is a substrate of a novel pathway that involves both SecYEG and YidC.
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