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  • Title: Selective pretreatment diagnostic imaging for detecting remote metastases in patients with endometrial cancer.
    Author: Heyer H, Ohlinger R, Arndt D, Belau A, Nehmzow M, Hosten N, Köhler G.
    Journal: Onkologie; 2006 Mar; 29(3):85-9. PubMed ID: 16514268.
    Abstract:
    OBJECTIVES: Various diagnostic tests are available to rule out metastases. However, not all of these tests provide significant information. Based on data collected at our institution, we have analyzed the significance of various imaging methods. PATIENTS AND METHODS: In 337 patients with fully staged endometrial carcinoma, the results of chest X-rays, bone scintigraphy, computed tomography (CT), magnetic resonance imaging (MRI) and ultrasonography of the liver, kidneys and abdomen were analyzed. RESULTS: In the 7 patients who showed metastases, the liver was the most frequently affected organ. Hepatic CT is associated with a likelihood ratio (LR) of 9.0, hence representing a valuable technique. In cases with a pretest probability of 1.19% (independent of the disease stage), CT results in a post-test probability of 9.78%, putting into question the usefulness of the method for confirming metastases. With all other analyzed diagnostic modalities, even less information is gained. CONCLUSION: The routine use of the above diagnostic methods, indiscriminate of the disease stage, is not justified. LRs provide an estimate of the information gained by a diagnostic procedure.
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