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  • Title: [The single administration of ethanol and the amplitude of the action potentials of the neocortical neurons in rats: extracellular studies].
    Author: Stashkevich IS, Maksimova LN, Sokolov SS, Gaziev AK.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1991; 41(2):372-83. PubMed ID: 1651626.
    Abstract:
    On outbred rats the influence was studied of acute administration of moderate dozes of ethanol (150 mg--1.2 g/kg, intraperitoneally) on the motor cortex neurones. It was shown that ethanol in the range of these dozes led to a change of the amplitude of extracellularly recorded action potentials, which could be directed to an increase or decrease. In the used range minimum as well as maximum dozes in various animals might elicit contrary effects, i.e. no dependence was observed of the direction of reaction of the studied neurones on the administrated doze. Possible mechanisms are discussed which may be the basis of the change of the amplitude of extracellular action potentials. Conclusion is made that use of moderate dozes of ethanol is a useful condition for studies directed to a search of mechanisms of initial reaction to alcohol action.
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