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  • Title: Coming up for air: HIF-1 and mitochondrial oxygen consumption.
    Author: Simon MC.
    Journal: Cell Metab; 2006 Mar; 3(3):150-1. PubMed ID: 16517402.
    Abstract:
    Hypoxic cells induce glycolytic enzymes; this HIF-1-mediated metabolic adaptation increases glucose flux to pyruvate and produces glycolytic ATP. Two papers in this issue of Cell Metabolism (Kim et al., 2006; Papandreou et al., 2006) demonstrate that HIF-1 also influences mitochondrial function, suppressing both the TCA cycle and respiration by inducing pyruvate dehydrogenase kinase 1 (PDK1). PDK1 regulation in hypoxic cells promotes cell survival.
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