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  • Title: Comparative study of azithromycin and amoxicillin/clavulanic acid in the treatment of lower respiratory tract infections.
    Author: Balmes P, Clerc G, Dupont B, Labram C, Pariente R, Poirier R.
    Journal: Eur J Clin Microbiol Infect Dis; 1991 May; 10(5):437-9. PubMed ID: 1651860.
    Abstract:
    Forty-eight patients with acute bronchitis and four with pneumonia were randomly assigned to receive five doses (500 mg on day 1, plus 250 mg/day on days 2-5) of azithromycin; 54 patients with acute bronchitis and four with pneumonia were assigned 30 doses (625 mg every eight hours for ten days) of amoxicillin/clavulanic acid (CA). The two regimens were equally effective, with clinical improvement or cure in 92% and 87% of patients respectively, bacteriological cure in 89% and 86%, with 91% and 89% of pathogens eliminated. Minor side effects occurred in 6% and 12% of patients in the two groups, respectively. No major abnormalities in laboratory safety parameters were seen in either group.
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