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  • Title: Determination of mitiglinide in rat plasma by high-performance liquid chromatography with UV detection.
    Author: Lushan Y, Su Z.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2006 Apr 13; 834(1-2):204-7. PubMed ID: 16520101.
    Abstract:
    A selective and sensitive high-performance liquid chromatography method has been developed and validated for determination of mitiglinide (MGN) in rat plasma using 2-(4-biphenylyl) propionic acid (BPA) as internal standard. Liquid-liquid extraction was used for sample preparation. Chromatographic separation was achieved on a C(18) column using acetonitrile and 0.02 mol/l KH(2)PO(4) buffer (pH 4.0) (45:55, v/v) as mobile phase delivered at 1.0 ml/min. The UV detector was set at 210 nm. The assay was linear over the range 0.1-20 microg/ml for MGN. The average extraction recoveries of MGN and BPA from rat plasma were 98.6 and 97.4%, respectively. The developed method has been applied to the pharmacokinetic study of MGN in rats.
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