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  • Title: [Isolation of a novel peptide that binds to BLyS from a 12-mer phage display peptide library].
    Author: Ding YL, Han W, Shen Q, Liu H, Yang SL, Gong Y.
    Journal: Yi Chuan; 2006 Feb; 28(2):208-11. PubMed ID: 16520318.
    Abstract:
    A 12-mer phage display peptide library was screened for specific binders against B lymphocyte stimulator (BLyS). After 3 rounds of panning, positive phage clones were enriched. ELISAs were used to identify positive phages, and the DNA encoding the positive peptide (RHKIQLRQNIIT) was cloned and expressed as a GST fusion protein in E. coli. After purification, the identity of the fusion protein was confirmed through its specific binding to BLyS by ELISA. We have obtained a peptide that can bind to BLyS and probably act as an antagonistic peptide against the natural BLyS receptor.
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