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  • Title: [A case of acinar-islet cell tumor of the pancreas body].
    Author: Machida H, Nakaya Y, Kojima K, Kanzaki M, Toda H, Tobayama S.
    Journal: Nihon Geka Gakkai Zasshi; 1991 May; 92(5):603-6. PubMed ID: 1652049.
    Abstract:
    Combined carcinoma of the pancreas is very rare. The case of pancreatic tumor featuring both acinar cell and islet cell tumors presented, may be only the fifth case of acinar-islet cell tumor in the world. A 34-year-old-woman visited our hospital complaining of weight loss (8 kg/6 months). A clearly demarcated pancreatic tumor was visualized by ultrasonography, body CT and MRI. Class 3 cells were extracted via ultrasonography guided fine-needle biopsy. Tumor was enucleated on October 5, 1988. Histologic appearance of the tumor by light microscopy was consistent with that of both acinar cell and islet cell tumors. Electron microscopy revealed two distinct populations of zymogen and neuroendocrine granules. The patient is doing well 1 year and 7 months postoperatively with no evidence of liver metastasis or recurrence. This case is significant in terms of the close histogenic relationship between pancreatic exocrine and endocrine components.
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