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  • Title: Ranolazine and late cardiac sodium current--a therapeutic target for angina, arrhythmia and more?
    Author: Makielski JC, Valdivia CR.
    Journal: Br J Pharmacol; 2006 May; 148(1):4-6. PubMed ID: 16520741.
    Abstract:
    Ranolazine is a new antianginal drug approved for clinical use in the United States in January 2006. A study published in this same issue of the British Journal of Pharmacology characterizes ranolazine block of late sodium current caused by the long QT syndrome 3 mutations. This commentary discusses the implications of that study and the background and implications for block of late cardiac sodium current in general.
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