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  • Title: [Effect of berberine, glaucine, stephaglabrine and sanguiritrine on neuromuscular transmission].
    Author: Bitkov VV, Khashaev Kh-, Pronevich LA, Nenashev VA, Batrakov SG.
    Journal: Neirofiziologiia; 1991; 23(2):131-5. PubMed ID: 1652103.
    Abstract:
    Natural alkaloid drugs, glaucine, stephaglabrine and sanguiritrine, are shown to affect the synaptic transmission in a fairly complicated manner and seem to involve several different mechanisms of action. These substances as well as berberine reduce amplitude of the spontaneous miniature end plate potentials in a frog neuromuscular junction. At low concentrations all the mentioned alkaloids diminish frequency of miniature potentials, but increase it when their concentration exceeds a certain value. Sanguiritrine is the most active in this respect (nearly a 100-fold increase), that is probably associated with its uncoupling effect on the mitochondrial oxidative phosphorylation. Sanguiritrine and stephaglabrine both cause repeated muscle contractions, that is in line with their anti-cholinesterase properties. Glaucine provokes only muscle contracture if present at relatively high concentration.
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