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  • Title: A new approach for the asymmetric total synthesis of umbelactone.
    Author: Liu H, Zhang T, Li Y.
    Journal: Chirality; 2006 May 05; 18(4):223-6. PubMed ID: 16521087.
    Abstract:
    The asymmetric total syntheses of (R)-(+)- and (S)-(-)-umbelactone were achieved by using the Sharpless asymmetric epoxidation reaction to generate the stereogenic center and a ring-closing metathesis (RCM) for the formation of the lactone structure. Starting from 3-methyl-2-buten-1-ol, the asymmetric total synthesis was achieved in an efficient 6-step protocol with an overall yield of 16%.
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