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  • Title: Oral ibandronate in the management of postmenopausal osteoporosis: review of upper gastrointestinal safety.
    Author: Epstein S, Delmas PD, Emkey R, Wilson KM, Hiltbrunner V, Schimmer RC.
    Journal: Maturitas; 2006 Apr 20; 54(1):1-10. PubMed ID: 16522358.
    Abstract:
    Oral daily bisphosphonates carry a potential for gastrointestinal (GI) adverse events, which has been partly addressed by introducing once-weekly regimens. Nevertheless, the need to follow inconvenient dosing instructions every week could still hinder long-term compliance and therapeutic outcome. In addition, survey data indicates that many patients would prefer a once-monthly rather than once-weekly bisphosphonate dosing regimen. Ibandronate is a potent, nitrogen-containing bisphosphonate specifically developed for less frequent administration. In a pivotal study in postmenopausal osteoporosis, oral ibandronate, administered daily or with a between-dose interval of >2 months, demonstrated robust antifracture efficacy and an overall incidence of upper GI adverse events similar to placebo, even in patients at increased risk of such events. This and other clinical studies conducted in postmenopausal women demonstrate that oral ibandronate has an excellent upper GI safety profile.
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