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  • Title: Effects of bistramide A on a non-small-cell bronchial carcinoma line.
    Author: Roussakis C, Robillard N, Riou D, Biard JF, Pradal G, Piloquet P, Debitus C, Verbist JF.
    Journal: Cancer Chemother Pharmacol; 1991; 28(4):283-92. PubMed ID: 1652385.
    Abstract:
    The antiproliferative effects of bistramide A, a nitrogenous dilactam polyether from Lissoclinum bistratum Sluiter (Urochordata), were studied at the level of the cell cycle in asynchronous cells of the NSCLCN6-L16 line. Bistramide A has a dual mechanism that induces blockade in the G1 phase (compatible with differentiation properties reported elsewhere) and causes polyploidy that is suggestive of inaptitude for cytokinesis. These effects confirm the results of cytomorphology studies in electron microscopy.
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