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  • Title: Isolation and purification of oridonin from Rabdosia rubescens using upright counter-current chromatography.
    Author: Lu Y, Sun C, Pan Y.
    Journal: J Sep Sci; 2006 Feb; 29(2):314-8. PubMed ID: 16524109.
    Abstract:
    A preparative counter-current chromatography (CCC) method for isolation and purification of oridonin, a new cancer chemoprevention agent, from the Chinese medicinal plant Rabdosia rubescens was successfully established. The crude oridonin was obtained by elution with a light petroleum/acetone solvent mixture from ethanol extracts of R. rubescens using column chromatography on silica gel. With a two-phase solvent system composed of n-hexane/ethyl acetate/methanol/water (1:2:1:2, v/v), 120 mg of oridonin at the purity of 97.8% was obtained from 200 mg of the crude sample in a single-step CCC separation. The structure of oridonin was identified by ESI-MS, 1H NMR, and 13C NMR.
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