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  • Title: Antimalarial effect of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-alkylpyridinium bromide).
    Author: Fujimoto K, Morisaki D, Yoshida M, Namba T, Hye-Sook K, Wataya Y, Kourai H, Kakuta H, Sasaki K.
    Journal: Bioorg Med Chem Lett; 2006 May 15; 16(10):2758-60. PubMed ID: 16524728.
    Abstract:
    The in vitro antimalarial activity of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-decylpyridinium bromide) and their derivatives, against the Plasmodium falciparum FCR-3 strain (ATCC 30932, chloroquine-sensitive) was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 3.5microM to 10nM. The chain length of the N1-alkyl moiety was found to be very beneficial in terms of antimalarial activity, and in this series of compounds, the most appropriate N1-alkyl chain length was found to be eight.
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