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  • Title: [Catalepsy and hyperkinesis induced by the chronic administration of a tetrapeptide into the rat neostriatum].
    Author: Iakimovskiĭ AF.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1991 Jan; 77(1):22-8. PubMed ID: 1652493.
    Abstract:
    The effect of bilateral intrastriatal daily microinjection of 5 and 15 micrograms of ley-enkephalin and its synthetic analog tetrapeptide during 3 weeks on behaviour, was investigated. No obvious effect was obtained after ley-enkephalin microinjections. The tetrapeptide produced obvious cataleptic status with plastic rigidity of skeletal muscles. Starting from the 2nd week of tetrapeptide microinjections, the upper arms developed a stereotyped hyperkinesis. No avoidance conditioning was possible. The findings suggest an involvement of the enkephalin neostriatal system in pathological behaviour as an analog of psychopathological disorders in humans.
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