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  • Title: Supramolecular catalysis of Strecker reaction in water under neutral conditions in the presence of beta-cyclodextrin.
    Author: Surendra K, Krishnaveni NS, Mahesh A, Rao KR.
    Journal: J Org Chem; 2006 Mar 17; 71(6):2532-4. PubMed ID: 16526812.
    Abstract:
    An environmentally benign and highly efficient procedure for the nucleophilic addition of trimethylsilyl cyanide to imines (Strecker reaction) has been developed under biomimetic conditions in water in the presence of beta-cyclodextrin to afford alpha-aminonitriles in quantitative yields. The use of cyclodextrin precludes the use of either acid or base, and the catalyst can be recycled a number of times without loss in activity.
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