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  • Title: Molecular cytogenetic analysis of leukemic mantle cell lymphoma with a cryptic t(11;14).
    Author: Aamot HV, Tjønnfjord GE, Delabie J, Heim S.
    Journal: Cancer Genet Cytogenet; 2006 Mar; 165(2):172-5. PubMed ID: 16527613.
    Abstract:
    We report a case of leukemic mantle cell lymphoma of the blastoid variant with complex chromosomal rearrangements leading to the recombination of BCL1 from 11q13 and IGH from 14q32. G-banding analysis showed, in addition to multiple other chromosome abnormalities, a del(11)(q13) and addition of unknown material to chromosome arms 13p and 21p. The two latter rearrangements were revealed, by use of multicolor in situ hybridization (M-FISH) analysis, to be a der(13)(qter-->p11::14q32::11q13-->11q22::14q32-->14q11::11q22-->11qter) and a similar der(21)(qter-->p11::14q32::11q13-->11q23::14q32-->14q11::11q22-->11qter). FISH with locus-specific probes for BCL1 and IGH showed a fusion signal on both derivative chromosomes.
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