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  • Title: Acute weight gain induced by amisulpride monotherapy in a first-episode schizophrenic patient.
    Author: Papadimitriou GN, Theleritis CG, Dikeos DG, Psarros CJ, Soldatos CR.
    Journal: Int Clin Psychopharmacol; 2006 May; 21(3):181-4. PubMed ID: 16528141.
    Abstract:
    The introduction of atypical antipsychotics into clinical practice has lead to an increase of adverse metabolic effects in psychotic patients. Amisulpride is a substituted benzamide derivative, and its use is associated with a lower risk of weight gain compared to other atypical antipsychotics. The case of an acute and excessive weight increase in a female first-episode schizophrenic patient who was treated with amisulpride monotherapy is reported. The improvement in psychopathology was remarkable. However, the patient gained 12.9 kg of body weight in the first 2 months of amisulpride administration and a total of 17.3 kg, 6 months after initiation of the treatment. Glucose and insulin levels, as well as a glucose tolerance test, remained normal throughout the observation period.
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